November 29, 2021

ALL-IN meta-analysis

Judith ter Schure, University of Leiden

Abstract:  The game-theoretic approach to statistical inference has major philosophical and mathematical advantages. Is it useful in statistical practice as well? This talk covers its use in the design of clinical trials that aim to contribute to an ALL-IN meta-analysis, for Anytime, Live and Leading Interim meta-analysis. We deal with practical problems in clinical trials, e.g. recruitment issues and lack of power, and reflect on ongoing debates in clinical trials and meta-analysis, e.g. about representativeness and random-effects modelling. We conclude that game-theoretic statistical inference has much to offer especially since it clarifies our goals and assumptions in clinical trial research.  See for more information.